Dose related zinc toxicity on liver

ABSTRACT

Zinc'citrate was given orally to forty animals for two months in various doses to study the histological changes in the liver. These observations revealed mild to moderate congestion, erosion of endothelium of central vein, fatty infiltration, prominent Kupffer cells and necrosis of hepatocytes as indicated by an increase in the cell size, granular cytoplasm and pyknotic nucleus. The liver glycogen was depleted in peripheral zones. The statistical analysis revealed a significant dose dependant increased necrosis of hepatocytes and glycogen depletion