mathematical modeling study of hippocampal theta rhythm in awake rabbits

ABSTRACT

Electroencephalographic [EEG] activity of the dorsal hippocampus [HC] of rabbits was recorded during three stages; before, during, and after a train of stimulating electric pulses were delivered to the reticular formation [RF]. Changes of frequency and amplitude of EEG activity within the theta frequency band [4-7Hz] were studied in great details. This work was accomplished by the use of a digital computer, programmed for online analysis of the data. The present results are best represented by a second order differential equation describing the dynamical behavior of the system as a forced oscillator. The obtained mathematical description agrees well with results obtained from animal experiment