use of quinine dihydrochloride during pregnancy: a hospital study, Sudan

ABSTRACT

122 pregnant women with chloroquine resistant malaria were treated with quinine during pregnancy, the regimen of quinine therapy was 10 mg/kg [600 mg] quinine dihydrochloride intravenous infusion thrice daily for the first 24 hours and then daily for a total dose of 8 infusions. All patients were cured except one who died after abortion. The outcome of pregnancy was available for 89 cases 76 of these 89 [85.4%] gave birth to normal living babies at term 4 [4.5%] abortions and 9 of the 89 [10.1%] pre term deliveries. There were two apparent congenital malformations in the term living babies. In conclusion, the regimen of quinine therapy adopted is satisfactory, effective and without serious complications to mother or foetus