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Effect of diltiazem and captopril on renal pathology in glycerol induced acute renal failure in rats
Tanta Medical Journal. 1993; 21 (1): 1315-1331
in English | IMEMR | ID: emr-31139
ABSTRACT
To evaluate the effect of pharmacologic vasodilators on glycerol induced acute renal failure, we studied untreated animals and those given Diltiazem and Captopril at a period of 24 hours 3 days and seven days after the onset of acute renal failure. At each time comparative assessment of renal histology were performed. Diltiazem a calcium channel blocker significantly reduced the extent of tubular cell necrosis and was associated with a more rapid histologic recovery. Captopril, an angiotensin converting enzyme inhibitor, did not influence renal pathology throughout the observation period. Diltiazem was benificial and offered significant protection against glycerol-induced acute renal failure in rats; it may have a protective effect at least in early stages of acute renal failure in humans
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Index: IMEMR (Eastern Mediterranean) Main subject: Rats / Diltiazem / Drug Therapy Limits: Animals Language: English Journal: Tanta Med. J. Year: 1993

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Index: IMEMR (Eastern Mediterranean) Main subject: Rats / Diltiazem / Drug Therapy Limits: Animals Language: English Journal: Tanta Med. J. Year: 1993