Studies on the teratogenic effects of clindamycin hydrochloride on the ckick embryo

ABSTRACT

Two doses [7.5 and 15 mg/50 g] of clindamycin hydrochloride were injected into the egg yolk of embryonated eggs of hens on the 5th day of incubation. Consistent effects of clindamycin were embryo lethality [100%], retardation of growth [10.3 to 10.7], ectopic viscera [34.5 to 42%] and a low incidence of anomalies like thin debilitated toes and feet [7 to 10.7%] and alopecia, respectively, [24.1 to 35.7%],. etc. Results suggested that exposure to clindamycin would cause serious reproductive problems in avian species