Effect of the synthetic pyrethroids sumicidin and S-3206 on male rat fertility

ABSTRACT

The effects of sumicidin and S-3206 on male rat fertility were studied on 5 groups of 30 mature rats each. Both sumicidin and S-3206 were orally administered in doses of 20.0, 100.0 and 1.0 and 5.0 mg/kg b. wt., respectively, for 65 successive days. Every 15 days, 5 rats from each group were killed for studying the changes in weights of sexual organs, epididymal sperm characters, the levels of FSH and LH in serum and the concentration of both insecticides in testes. Both drugs significantly decreased the weights of male reproductive organs, sperm count, percentages of sperm motility and seminiferous tubules containing spermatozoa. They increased the percentage of sperm abnormalities, while the levels of FSH and LH in serum were fluctuated