Study of some acute phase reactants in chronic renal failure before and after hemodialysis

ABSTRACT

Thirty subjects were available for this study, they were divided into three equal groups group I ten patients with chronic renal failure [CRF] on regular hemodialysis, group II ten patients with C.R.F., on conservative therapy, group III ten healthy subjects served as control. Serum C-reactive protein [C.R.P], haptoglobin [HPT] and alpha-1-acid glycoprotein [AAG] as acute phase reactants were estimated for all subjects and for the hemodialysis group before and after hemodialysis. The estimation was done by Turbi-Timer method. Unlike CRP, the AAG has a significant value in hemodialysis patients, while HPT, like CRP, cannot be recommended as an acute phase reactant in these patients because of the unacceptable high false positive rate. In the uremic [non dialysed] patients, the CRP maintains its diagnostic value then comes the AAG whose level is correlated with the degree of renal impairment. On the contrary, HPT cannot be recommended because of high false positive rate