Induction of immune complex glomerulonephropathy in rabbits exposed to formalin vapour: a condition resembling human goodpastures syndrome

ABSTRACT

Forty two rabbits were used to induce glomerulonephropathy by exposure to 10% formalin vapour. Seven groups of rabbits were exposed to formalin vapour at a rate of twenty three hours per day and one hour ventilation for eight successive months. The results showed that IgG was deposited in 50% of the glomeruli accompanied by histological changes occurred in most of the glomerular tufts. The lesions all together resembeled Goodpastures syndrome of man