new treatment modality proposed for the management of denture sore mouth

ABSTRACT

A study on chronic denture stomatitis was presented and two current methods of management were evaluated. The concept of use of hygenic regimen for dentures was discussed and proved to be helpful among 15 patients representing the control group. Bis-triazole, a new oral antifungal drug was used in the treatment of 15 patients suffering from denture sore mouth. Drug syrup used intra-orally under dentures was found to be effective in the treatment of denture stomatitis [50 mg on a divided dose of 5 mg/ml, 150 ml/bottle]; the daily dose for a fortnight was suggested as an adequate course of treatment. The achieved clinical improvement during the follow-up periods was proved to be statistically highly significant. For quantifying this improvement, st and ard subjective criteria were developed; namely, lesions, pain, duration and inflammation. C and ida albicans was isolated from all cases of denture sore mouth [30 patients]. Although mycological assessment showed a high rate of negativism at the 7th day of therapy, recolonization was observed in 2 patients at the end of 14th day of therapy, giving a satisfactory mycological cure. The drug therapy did not induce changes in blood picture as well as renal and liver function tests. The drug was well tolerated in almost all cases, mild and transient nausea and diarrhea were reported in only one patient. Finally, the disorders which may result from a persistent oral infection by C and ida should be considered the main target of management and underline the necessity for adequate treatment of this disease entity