Spectrophotometric determination of mequitazine and thiopentone sodium in dosage forms

ABSTRACT

A simple and sensitive spectrophotometric method was described for the determination of mequitazine and thiopentone sodium. The method was based on the formation of ferroin upon reaction of these drugs with iron [III]-o-phenanthroline reagent. The colored product was quantitated spectrophotometrically at 510 nm. Beer's law was obeyed over concentrations ranging from 0.2 to 0.8 mg% and 2 to 6 mg% for mequitazine and thiopentone sodium, respectively. The proposed method has been applied successfully to the determination of the investigated drugs in dosage forms