Compatibility study between ibuprofen, indomethacin, tolbutamide and glibenclamide and some tablet excipients using differential scanning calorimetry

Differential scanning calorimetry [DSC] was used to investigate the interactions between selected drugs; namely, ibuprofen, indomethacin, tolbutamide and glibenclamide, and a number of commonly used tablet excipients. Ibuprofen, tolbutamide and glibenclamide were found to interact with magnesium stearate and lactose, but no interaction was observed with the other excipients used. Indomethacin interacted only with lactose