Luteal phase defect with different lines of treatment for induction of ovulation

ABSTRACT

The prevalence of luteal phase defect [LPD] with different drugs, for induction of ovulation, was studied in 71 infertile women. LPD was diagnosed when an endometrial biopsy, obtained on the 22nd day, showed a histologic lag of 2 days or more. Ultrasound scan [USS] was used for study of follicular growth and prediction of ovulation. Insler cervical score from day -4 to day 0 was done, estradiol [E2] in serum in day 0 and mid-luteal, and progesterone [P] mid-luteal were measured. Prevalence of LPD with antiestrogen, bromocriptine and HMG/HCG was 38%, 15.4% and 22%. Cervical score showed good predictive value for LPD from day -2 to day 0 [F 0.0001]. Neither serum E2 nor P showed predictive value of LPD