Anorectic drugs, diet and serum proteins interrelationship in rats

ABSTRACT

The effect of two anorectic drugs [phentermine and diethylpropion] on serum total proteins and protein fractions were tested in rats. Two doses [10 and 30 mg/kg body weight] of each drug were tried and their effects were compared with pair fed control groups. The effects of the two drugs were studied when two different diets [high sucrose and high butter fat diet] were fed for 10 days. The picture of serum total proteins and protein fractions was completely different when changing the type of diet. On feeding high butter fat diet, phentermine produced significant increase of serum total proteins, albumin and alpha2 globulin. However, when high sucrose diet was fed, phentermine produced significant increase of gamma globulin and decrease of alpha-1 globulin. Diethylpropion produced a significant increase of gamma globulin and a significant decrease of albumin/globulin [A/G] ratio, when feeding high butter fat diet. On feeding high sucrose diet, diethylpropion produced significant decrease of albumin and A/G ratio