Spectrophotometric determination of amikacin through its complication with cu [II] ion

ABSTRACT

A spectrophotometric method was developed for the determination of amikacin in pharmaceutical forms. The method depends on its complexation with Cu [II] ions, in slightly alkaline medium using tartrate as an auxiliary ligand. It was found that Cu [II] complexes with amikacin in the ratio 11 [Cu amikacin], and the value of log beta 1 constant of the complex was found to be 6.8. The proposed method was used for the estimation of amikacin in pharmaceutical preparations with suitable accuracy