Atomic absorption spectrophotometry for the determination of some antihypertensive agents

ABSTRACT

Atomic absorption spectrophotometric methods for the determination of oxprenolol hydrochloride, indapamide and captopril were developed. The methods were based on the determination of oxprenolol hydrochloride and indapamide via their chloride contents and captopril via its sulphur content. In case of oxprenolol hydrochloride, an excess of standard silver nitrate was added, the precipitated silver chloride was centrifuged and the silver contents of both the precipitate and the decanted solution were determined by atomic absorption spectrophotometry. In case of indapamide, oxygen flask combustion method was first carried out. Captopril was ashed using oxygen flask combustion method, followed by adding a known excess of barium chloride and the precipitated barium sulfate was centrifuged. The excess barium chloride in the decanted solution was determined by atomic absorption spectrophotometry