Massive gingival overgrowth leading to the diagnosis of Ehlers-Danlos syndrome: review of the literature and report of a case

ABSTRACT

The Ehlers-Danlos syndrome [EDS] is a connective tissue disease characterized by abnormalities of collagen molecules. At least eleven forms of the disease, based upon the biochemical and clinical characteristics, have been identified Type IV EDS has been identified by deficiency of Type II collagen and causes life-threatening damages to major blood vessels and internal organs. Type VIII EDS has been characterized by advanced periodontitis causing early exfoliation of teeth in young adults and children. These original concepts are questioned with the recent observation that advanced periodontitis has been reported in Type IV EDS. Re-appraisal of early classifications is recommended. The case presented adds a new clinical feature to the periodontal abnormalities with no alveolar bone reabsorption in EDS