Schistosoma mansoni: IgG reactivity to soluble adult worm antigen preparation [swap] in sera of immunized mice with irradiated attenuated and virulent cercariae

ABSTRACT

The aim of this work was to identify the antigens, that elicit a greater or unique immune response in the immunized host against Schistosoma mansoni [Egyptian strain] infection. Moreover, the difference in immune response to this antigen between mice immunized with radiation-attenuated cercaria or immunized with virulent cercaria were investigated. Immunoblotting technique was used to monitor the fine specificity of host IgG to SDS-PAGE separated SWAP in the sera of different test groups immunized with either radiation-attenuated cercaria or low doses of virulent cercaria compared with non-immunized group