Thyroid function in patients with chronic renal failure

ABSTRACT

Ninety-four patients with chronic renal failure were categorized into three groups twelve conservatively-treated patients, nineteen patients treated by peritoneal dialysis, and sixty-three patients treated by haemodialysis [HD]. Thirty-eight healthy subjects were used as controls. All patient groups studied showed a reduction in serum total thyroxine [T4] and serum total triiodothyronine [T3] with normal serum thyroid stimulating hormone [TSH]. All conservatively-treated patients [group 1] exhibited significant reduction [P<0.01] in serum T4 and T3 values when compared with the control group. Fifty-three% of patients treated by peritoneal dialysis [group II] displayed a significant reduction [P<0.05] in serum T4 in comparison with the control group, an eighty-four% of Them had lower serum T3 values [P<0.01]. Eighty-nine% of patients nested by haemodialysis [group Ill] Showed a reduction in total T4, while sixty% of patients remained with low serum T4 post-dialysis [P<0.05]. Seventy nine% of group Ill demonstrate low serum T3 values predialysis, and fifty-two patient of them had reduced serum T3 after dialysis [P<0.05]. A different of low serum T4 and T3 syndrome in the three groups studied may be suggested. The mean serum TSR value could not be taken as a parameter to depend upon due to individual variations