Treatment of pulmonary tuberculosis comparison of three therapeutic regimens

ABSTRACT

The effectiveness of three antituberculosis regimens were evaluated and compared on 175 patients with active pulmonry tuberculosis. Patients were assigned to one of three treatment regimens according to a randomized schedule of 1-Nine months regimen; initial two months of [2RHSRH7] Rifaimpicin 0.45 g/d-0.6 gm/d + isoniazid 0.3 gm/d + streptomyein 0.75 gmd-l gm/d. Continuation phase seven months of Rifampiein 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d. 2-Six months regimen [2RH-ISZ/RH4]; initial two months of Rifampicin 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d + streptomycin 0.75 gm/d-I gm/d ' pyrazinaminde 1.5 gm/d-2 gm/d. Continuation phase four months of Rifampicin 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d. 3 months regimen [2RHZIRH4]; initial phase two months of Rifampicin 0.45 gm/d-0.6 gu + isoniazid 0.3 gm/cl + streptomycin 0.75 g gm/d + pyrazinaminde 1.5 gmld-2 guild. Continuation phase four months of Rifampiein 0.45 gmfd-0.6 guild + isoniazid 0.3 gm/d. 118 patients completed the course of treatment, 7 patients defaulted, 4 patients were excluded because they could not tolerate the effects of side effects of drugs, and 6 patients remained bacillary exceretors i.e. became chronic cases. All these regimens produced significant effectiveness [P<0.05], but the second regimens [2RHSZ/RHI4] is the most highly effective than the other two regimens [P< 0.05]