Angiolymphoid hyperplasia with eosinophilia and Kimura's disease: a clinicopathological study

ABSTRACT

In this work, the clinical and histopathological features of 10 cases of angiolymphoid hyperplasia with eosinophilia and 5 cases of Kimura's disease are described and a comparison between the features of the two lesions is presented. Angiolymphoid hyperplasia showed exuberant proliferation of vessels lined by plump endothelial cells with irregular nuclei and cytoplasmic vacuoles, together with fibromyxiod matrix and inflammatory cells infiltrate containing eosinophils. Involvement of muscular coat of blood vessels or even growth entirely within a vessel was a common feature. It occurred in the skin and subcutaneous tissue. Kimura's disease occurred in the parotid gland and the subcutaneous tissues. It was characterized by florid lymphoid infiltrate with prominent lymphoid follicle, vascularization of germinal centres, germinal centre necrosis with eosinophilic material [folliculolysis], and marked eosinophilia with or without eosinophil abscess formation