Clustering of major chromosomal abnormalities among azoospermic males in Kuwait: a study of 280 patient

ABSTRACT

Two hundred and eighty cases of azoospermic males were confirmed in the Kuwait Medical Genetics Centre from Jamjar 1979 to December 1992. Major chromosomal abnormalities were found in 40.7% of the patients including cases of klinefeter's syndrome [34.6%] and structural chromosomal rearrangements [4.3%]. In this study, the ratio of numerical to structural chromosomal abnormalities was 8.11 and XX males represented 1.8% of azoospermic men. The calculated average parental inbreeding coefficient was 0.02055. The data are compared with those of a previous study of oligospermic and azoospermic men in Kuwait and with other worldwide surveys