Propofol versus midazolam antagonized by flumazenil after completion of surgery in day case surgery

ABSTRACT

In this study, speed of recovery was evaluated by using sedation scores in 45 male patients ASA I or II presented for diagnostic cystoscopy under general anesthesia. Induction of anesthesia was started in groups I and II [15 patients each] with mean [SD] doses of [0.17 + 0.06 mg/kg] or [0.17 + 0.04 mg/kg] midazolam, respectively, group II received i.v. flumazenil [0.54 + 0.17 mg/kg] after completion of surgery. Group III [15 patients] received propofol [1.60 + 0.23 mg/kg]. Anesthesia was maintained with isoflurane in 33% oxygen and nitrous oxide in all patients. Flumazenil showed tendency to improve tests of recovery after midazolam anesthesia, but faster recovery was significant in propofol group. Recovery after propofol anesthesia was associated with better psycomotor test results and less impairment of mental state as judged by sedation and amnesia scores