Influence of male sex hormone on some hepatic enzymes in liver for non-castrated and castrated male rats

ABSTRACT

Effect of testosterone on liver functions was studied. Administration of testosterone led to significant elevation in serum alanine and aspartate aminotransferases in both noncastrated and castrated groups, but the levels were lower in castrated group than in noncastrated group. On the other h and, levels of these enzymes in homogenated rat livers were low as a result of testosterone treatment. In addition, no significant changes were recorded in serum proteins in treated rats with testosterone, but the levels of proteins were low in homogenated rat livers in noncastrated and castrated rats. Testosterone did not elevate serum bilirubin in noncastrated rats. Finally, estimation of serum testosterone revealed significant rise in noncastrated and castrated male rats after administration of testosterone