Influence of female sex hormones on nucleic acid metabolism in diabetic females rats

Effect of combined estrogen-progesterone [EP] on DNA and RNA contents of liver and kidney in nondiabetic and diabetic female rats was studied. RNA content was elevated in liver, while DNA content was not affective after treatment with EP. But in kidney, EP treatment had no effect on RNA content. Diabetes caused reduction in RNA and elevation in DNA content in highly significant effects in both liver and kidney. Ovariectomy had no effect on RNA and DNA of kidney, but it caused significant elevation in RNA and DNA contents in liver