role of repetitive human chorionic gonadotropin supplementation in decreasing early pregnancy wastage

ABSTRACT

Eighty women in their early pregnancy [5th week] were divided into two equal groups, the first group received 3000 I.U. human chorionic gonadotropin [HCG] intramuscularly twice/week from the 5th till 8th week of pregnancy while the second group received no HCG treatment. Each group was further divided equally into 2 subgroups each of 20 patients. The patients in the first subgroup were those who conceived after clomiphene citrate [CC] treatment for induction of ovulation. Those in the second subgroup were the patients who conceived spontaneously and with a past history of early abortions. In the HCG treated group, 6 out of 40 patients aborted [15%] compared to 16 out of 40 patients [40%] in those who were not treated with HCG [P <0.01]. HCG supplementation during early pregnancy decreased the percentage of pregnancy wastage from 45% in 15% in patients who conceived on CC or CC/HCG induction of ovulation [P <0.01]. Also, HCG treatment decreased pregnancy wastage% from 35% to 15% in patients who conceived spontaneously and having a history of previous abortions [P <0.01]