Genotoxic effects of pirmor on the germ cells of Drosophila melanogaster

ABSTRACT

Pirimor, a carbamate pesticides, was evaluated for its genotoxic effects on male germ cells and sterility in Drosophila melangogaster, by the well-known sex linked recessive lethal test. 2 concentrations LC50 and LC5 [0.47% and 0.33%] were used following one route of administration adult feeding. After single exposure, the results showed that at high concentration Pirimor induced significant increase of mutation frequencies in the first 2 broods of spermatogenesis which decreased gradually in the other germ-cell stages. On the contrary, value of lethals at LC5 [0.33%] were insignificant in all broods of spermatogenesis. Steriles induced by Pirimor were higher in the first 2 broods than the others stages at both concentrations. Lethalities as well as sterility exhibited a concentration and stage-dependent effect