Evaluation of the sedative and some anticholinergic effects of the H1 antagonists loratadine and pheniramine in experimental animals
New Egyptian Journal of Medicine [The]. 1994; 10 (6): 2467-70
in English
| IMEMR
| ID: emr-34407
ABSTRACT
All antihistaminic drugs have adverse effect of some degree. The most common side effects are sedation and anticholinergic responses. On isolated rabbit jejunum pheniramine [1-2 ug/ml] reduced significantly contraction induced by a submaximal dose of acetylcholine. However, loratadine [1-16 ug/ml] produced no reduction. Loratadine in doses up to [300 mg/kg] which is more than 300 times the effective antihistaminic dose, produced no significant effect on spontaneous motor activity in motor coordination nor in parkinsonism induced by fluphenamine [10 mg/kg s.c] in adult rats. On the other hand, pheniraine [5 mg/kg] intraperitoneal reduced significantly spontaneous motor activity and motor coordination in experimental rats. Like loratadines, it has no effect on fluphenazine induced parkinsonism. It can be concluded that loratadine is a nonsedating antihistaminic with no peripheral or central anticholinergic effects even in doses 300 times the antihistaminic dose. So, it is a safe and well tolerate
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pheniramine
/
Loratadine
/
Histamine H1 Antagonists
Limits:
Animals
Language:
English
Journal:
New Egypt. J. Med.
Year:
1994
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