Effect of adrenaline administration on the histological structure, lipid and ascorbic acid contents of mouse adrenal cortex

ABSTRACT

The adrenal glands were taken from 9 male mice after a single intraperitoneal injection of 0.03/100 g body weigh of adrenaline hydrochloride solution at different periods of time 0.5 hour, one hour and 2 hours [3 at a time]. The histological structure, lipid ascorbic acid contents have been studied. The results obtained in the present study showed that, the most obvious changes were seen as follows Dilatation of cortical sinusoids, loss of subglomerulosal zone, and transformation of the fasciculate cells from the clear to dark type. Depletion of sudanophilic materials from zona reticularis and zona fasciculata started at 0.5 hour after injection with maximal depletion at 2 hours after injection. A single adrenaline injection caused a rapid fall in ascorbic acid content at 0.5 hour after injection. One hour after injection there was complete ascorbic acid depletion from zona glomerulosa and outer zona fasciculata