Ultrastructure changes of the pituitary gland of rat after garamicin treatment

ABSTRACT

An antibiotic drug of the aminoglycoside group gentamicin [commercial name garamycin] was used in the present study. The ultrastructural changes induced in pituitary gland of female albino rat by intraperitoneal injection of daily 5 doses double therapeutic dose [1O mg/kg body weight] of garamycin were studied and examined on the 5th day post treatment. Garamycin, affected the releasing and synthesising activity of prolactin, leutinizing hormone [LH], follicular stimulating hormone [FSH], growth hormone [GH] and adrenocorticotrophic hormone [ACTH]. Prolactin and leutinizing hormones stimulate estrogen and progesterone, follicular stimulating hormone, stimulus ovary follicles production, while growth hormone for development and ACTH stimulates the functions of the adrenal cortex. Post-treatment pathological changes appeared in most secretory cells of the pituitary glands. Generally, cells appeared degranulated with dilatation of RER and Golgi apparatus, swollen and aggregation of mitochondria and irregularity of cell membrane. Nuclear changes were also prominent