Paraproteinemia in chronic lymphoproliferative disorders

ABSTRACT

49 patients suffered from chronic lymphoproliferative disorders were classified according to the clinical diagnosis. The classification and typing of serum paraproteins in these cases were investigated by using both immunofixation and radial immunodiffusion techniques. The monoclonal protein was found in 90% of the cases with multiple myeloma, 77.77% with Waldenstrom's macroglobulinemia, 50% with chronic Iymphocytic leukemia, and 55.55% with non-Hodgkin's lymphoma while, the cases with Hodgkin's disease showed no detectable amount. The high proportion of the patients with different type and amount of abnormal protein might be referring that the appearance of paraproteins in serum could be used as tumor marker