T3 and T4 hormones behavior in acute myocardial infarction

ABSTRACT

The main criterion for inclusion in study was freedom from diseases that may affect level of thyroidal hormones, subjects with history of drug intake that may affect thyroid function were excluded. All subjects underwent clinical examination, ECG, cardiac enzymes determination, some laboratory investigations and T3 and T4 radioimmunoassays on admission then on third and seventh days post AMI. The results showed a significant and transient decrease in TT3 and TT4 in early three days of AMI which returned to normal on seventh day after AMI. There was no significant relationship between TT3 and TT4, on one hand, and site or size of AMI, on the other hand. Also, there was no relationship of TT3 and TT4 and presence or absence of heart failure, however, patients with post myocardial infarction angina had a significantly higher TT3 in the day preceding the angina attack. So, it seems that this thyroidal hormones changes in adaptive process to limit the catabolism in such circumstances resulting in decrease of O2 consumption