Gamma-glutamyl transferase as a biochemical marker of endothelial damage in gestational hypertension

ABSTRACT

Gamma-glutamil transferase [GGT] and serum alkaline phosphatase, serum electrolytes and uric acid were measured in the study and control women. 13 women met strict criteria for the diagnosis of preeclampsia [PET], 7 women with gestational hypertension alone [PIH] and 20 normal pregnant women were selected from the same cohort and matched according to race, age, parity and gestational age [32-36 weeks]. There was a significant difference between the GGT concentration in PET [mean 27.3 +/- 1.65] and control [mean 15.76 +/- 0.721] women. Also, significant difference between PIH patients [mean 23.6 +/- 0.93] and control women. Uric acid concentration, serum sodium [S. Na] and serum potassium [S. K] concentrations differ significantly between PET patients [mean 3.9 +/- 0.34, 147 +/- 1.82, 4.64 +/- 0.18, respectively] and the control women [mean 2.52 +/- 0.216, 138.9 +/- 0.77, 4.1 +/- 0.04, respectively]. No significant difference was found in the concentration of S. uric acid, S. Na, S. K in the PIH patients and control women. It was found that, there is no difference in the serum alkaline phosphatase between either groups of gestational hypertension and the control group