Cytological study on the effect of the food preservative sodium nitrite and pyrethoid insecticide polytrin on some mammalian organs

ABSTRACT

The purpose of the present work was to study the synergestic effect of food preservative sodium nitrite and pyrethroid group of insecticide "polytrin" on the Golgi apparatus of the liver, kidney and spleen cells of male albino rat, and to study the effect of each of those chemicals separately. Polytrin was injected intraperitoneally with a single sublethal dose [1/50 LD50] for two days and sodium nitrite was given at a dose of [2 g/L of water] daily for 90 days by the oral route. The Golgi apparatus has proved to be highly sensitive to polytrin and sodium nitrite treatment. Fragmentation, atrophy and coarse of Golgi apparatus appeared to be a consequence of the destruction of the membrane systems or the suppression of the lipoprotein synthesis necessary for membrane formations