Urinary fibrinogen degradation products in children with hematuria

ABSTRACT

Urinary fibrinogen degradation product [U-FDP] concentrations were determined in 60 pediatric patients with hematuria using the latex particle agglutination test [LPAT] to assess the value of this test for the localization of the site of hematuria. The cases were divided into 2 groups, 30 cases each, according to the site of origin of hematuria. Only 4 cases [13.3%] with glomerular hematuria showed marked increase in U-FDP concentrations >0.25 ug/ml while, 26 cases [86.7%] with nonglomerular hematuria showed such high concentrations or more. The sensitivity and specificity of using U-FDP levels in localizing the site of hematuria was 86.7% both, which seems to be compensated with combined urine analysis for erythrocyte cylindruria. In conclusion, U-FDP concentrations by LPAT can help in localizing the site of bleeding in cases of hematuria