relation between obstructive jaundice, endotoxemia and renal functions

ABSTRACT

This study showed that acute renal failure is one of the commonest complications in patients with obstructive jaundice and is a major cause of death. Besides, systemic endotoxemia is the prime cause of renal failure, treatment of endotoxemia by adding oral lactulose to the preoperative prepration of patients prevents acute renal failure and improves the renal functions. Bilirubin may have no role in occurrence of renal failure in these patients, the preoperative preparation with vitamin K, systemic antibiotics, preoperative hydration and mannitol may not be edequate and the addition of an antiendotoxic agent as lactulose is highly recommended