Curative role of isologous bone marrow transplantation on radiation induced histochemical changes in bone marrow of rat

ABSTRACT

This work is a comparative study of radiation injury on bone marrow enzymes; namely, alkaline phosphatase and peroxidase, and possible control by the isologous bone marrow transplantation. The present study showed increased levels of alkaline phosphatase and peroxidase enzymes in bone marrow cells after radiation exposure. The level of enzymatic activity under investigation could be significantly restored over 3 weeks post-exposure of 6 Gy of gamma irradiation. The results obtained demonstrated the efficacy of bone marrow transplantation for replacement or proliferation of injured hematopoietic tissue component and, consequently, more rapid restoration of the normal levels of enzymatic activities in the irradiated bone marrow