Effect of long acting bromocriptine on the endometrium of adult female albino rat II an electron microscopic study

ABSTRACT

Long acting bromocriptine injections were intramuscularly administered to adult female albino rats. Each rat received a single dose equivalent to either the low or high human therapeutic dose. Uterine specimens were collected 2 and 15 days after the injection to study the effect of the drug on the endometrium. Both doses markedly increased the thickness of the uterine epithelial lining due to focal transformation of the normal simple cuboidal or low columnar epithelium into tall columnar, pseudostratified or even stratified columnar epithelium. According to their fine structure, both the epithelial lining and the glandular epithelium in the control animals contained only one type of cells. However, 2 days after the low dose injection the cells were differentiated into 3 types, the pale, the dark and the intermediate reflecting different degrees of cellular protein synthesis activity. Two days after the high dose injection both the lining and glandular epithelia were transformed into the pseudostratified columnar and tall columnar type, respectively