Effect of oral bromocriptine on the endometrial structure of adult female albino rat

ABSTRACT

The response of the endometrium to oral bromocriptine administration in low and high doses for 30 days and the effect of the drug withdrawal, 15 days after the last dose, was studied in adult albino rat. Both doses increased the thickness of the endometrial epithelial lining due to focal transformation into the pseudostratified columnar or even the stratified columnar types. However, the latter type was seen only in high dose-given animals. The cytoplasm of most of the epithelial cells was vacuolated. These vacuoles were variable in shape and size and contained lightly stained eosinophilic material and deeply stained basophilic granules. Both doses increased the thickness of the glandular epithelium of some glands where the epithelium was transformed into the pseudostratified columnar type. However, some other glands were abnormally cystically dilated and lined by simple squamous epithelium. Bromocriptine administration in its low and high doses markedly increased the size of the stromal cells which contained abnormally abundant cytoplasm and oval or rounded vesicular nuclei