Comparative study on susceptibility of Leishmania isolated from dermal leishmaniasis to antifungal drug terbinafine and classic antileishmanial drugs

ABSTRACT

Antileishmanial activity of Terbinafine, Sodium stibogluconate and Meglumine antimoniate against Leishmania tropica promastigotes was compared. The minimum inhibitory concentration [MIC] of Terbinafine was 400 g/ml of fluid phase of medium while MIC of Sodium stibogluconate was 750 g/ml of fluid phase of medium. In case of Meglumine antimoniate, 1000 g/ml failed to inhibit the growth of L tropica promastigotes. Thus, in vitro effect of Terbinafine was superior to Sodium stibogluconate and Meglumine antimoniate in terms of concentration of drug required to inhibit the growth of L. tropica promastigotes