Lack of sodium salicylate-induced enhancement of hepatic tryptophan pyrrolase in 5 day salicylate injected rats
Pakistan Journal of Biochemistry. 1994; 27 (1-2): 81-85
in English
| IMEMR
| ID: emr-35112
ABSTRACT
Single administration of sodium salicylate at doses of 400 mg/kg increased hepatic holo-tryptophan pyrrolase activity but did not produce any effect an apotryptophan pyrrolase activity in rats. Repeated administration of the drug at doses of 100 mg/kg did not alter holo-enzyme activity but decreased apo and total enzyme activity in rats killed 24 hours later. Administration of 400 mg/kg sodium salicylate to 5 day, 100 mg/kg sodium salicylate injected rats did not increase holo or apo-tryptophan pyrrolase activity. Possible role of tryptophan pyrrolase in the sodium- salicylate induced changes of brain serotonin metabolism is discussed
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Tryptophan Oxygenase
/
Sodium Salicylate
/
Liver
Limits:
Animals
Language:
English
Journal:
Pak. J. Biochem.
Year:
1994
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