Inclusion complexion of ketoprofen with B-cyclodextrin and hydroxypropyl B-cyclodextrin in water and in solid state
SPJ-Saudi Pharmaceutical Journal. 1994; 2 (1): 2-7
in English
| IMEMR
| ID: emr-35604
ABSTRACT
Inclusion complexation of ketoprofen with beta -cyclodextrin[beta -CD] and hydroxypropyl beta cyclodextrin [HP beta -CD] in aqueous solutions and in the solid phase were examined by phase solubility diagrams, infrared spectroscopy, and diffraction patterns. Ketoprofen-cyclodextrin inclusion complexes were obtained applying different techniques including spray drying, freeze drying, evaporation under vacuum and co-grinding in presence and absence of water. The dissolution profile of ketoprofen was highly improved in the complexed from compared to non- treated ketoprofen or its physical mixtures with either- beta CD or HP beta-CD in the same ratio
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Cyclodextrins
Language:
English
Journal:
Saudi Pharm. J.
Year:
1994
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