Synthesis of some new 4 [3H] -Quinazolines as potential anticonvulsants
SPJ-Saudi Pharmaceutical Journal. 1994; 2 (1): 21-31
in English
| IMEMR
| ID: emr-35606
ABSTRACT
Condensation of various 4H-3.1 benzoxazin-4-ones [III] with homoslfanilamide afforded some new derivatives of 3-[p-sulfamoylbenzyl]-4 [3H]-quinzolinone [V]. Some o-amido-N- [p-sulfamoylbenzyl]-benzamides [IV] were isolated as reaction intermediates. Structures of the newly synthesized compounds were confirmed by IR, 1H-NMR, MS and elemental analyses. Several target compounds [V] exhibited good anticonvulsant effects against pentylentetraxol -induced convulsions in frogs. Compound [V-4] was 2.33 times as potent as phenobarbitone
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Quinazolines
/
Anticonvulsants
Language:
English
Journal:
Saudi Pharm. J.
Year:
1994
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