Lipid profile in B-thalassemia

ABSTRACT

As the liver damage in B-thalassemia might account for the decrease in serum total cholesterol, LDL and HDL-cholesterol concentrations, this work was carried out to study the behaviour of lipid profile in thalassemia children. The study comprised 40 patients with Beta-thalassemia major and 10 cases as a control. All children were subjected to full history taking and clinical examination as well as the following investigation. Blood picture, liver functions as well as estimation of serum cholesterol, triglycerides, LDL and HDL cholesterol. Our results revealed that the levels of serum lipids are affected in patients with B-thalassemia. There was a decrease in serum total cholesterol, LDL-C, and HDL-C concentrations to control. While triglyceride level is of non-significance in patients with B-thalassemia. These changes revealed that liver damage in this disease might account for the changes in the serum lipids. Therefore the evaluation of serum lipids in thalassemia patients is necessary to study its sequela on body organs