Topical 5-fluorouracil versus mitomycin-c in management of pterygium

ABSTRACT

44eyes primary pterygia were treated by surgical excision with bare sclera 2 - 3 mm followed by topical instillation of 0.02% mitomycin-c twice daily for 5 days [20eyes], and 5-Fluoro uracil 4 times for 2 weeks [24 eyes]. Both medications reduce the recurrence rate of pterygia. To 5% in cases treated with mitomycin-c and 8.3% in cases treated with 5-fluoro-uracil after 6 months follow-up period. The result of the study showed that mitomycin-c is more effective than 5-Fluoro uracil, better tolerated by the patients and with Lesser complications