Primary central nervous system lymphoma [PCNSL] clinical, radiological, histopathological and immunological evalution. comparison with other CNS lymphomas

ABSTRACT

Fifteen cases of CNS lymphomas are included in the present study. 7 cases of primary central nervous system lymphoma [PCNSL] 6 cases of spinal lymphomas, and 2 cases of lymphomatous lyptomeningitis. In PCNSL patients the male to female ratio was 4-3, the initial clinical presentation tion in 4 cases [60%] was in the form of TIAS [transient ischaemic attacks], Rinds [reversible ischaemic neurologic deficits] and stroke that preceeded the clinical diagnosis of lymphoma by a mean duration of 8 months. Radiologically PCNSL was subclassified into periventricular [central] type and cortico-meningeal [peripheral] type each had a characteristic lines of spread. Staging procedures did not demonstrate the existence of extraneural dissimination in PCNSL. All cases of spinal lymphomas occurred in the dorsal regions and was associated with extensive epidural disease that involved multiple vertebral segments. Lymphomatous lyptomeningitis was presented clinically with multiple cranial nerve and quada roots affection. Staging was associated with extensive extra-neural dissimination in both spinal lymphoma and lympho matous lyptomeningitis patients. Lines of treatment and follow up of cases will also be discussed