role of 99m Tc-sulphur colloid in detecting the relationship between hepatic kupffer cells dysfunction and intrinsic asthma

ABSTRACT

This study was carried out at both Departments of Medicine and Radiotherapy and Nuclear Medicine Ain Shams University Hospitals between January, 1992 and February 1993. It included 2 groups. The first group consisted of 20 patients having criteria suggestive of intrinsic asthma [6 males and 14 females], their ages varied between [31 and 55 years]. The second group [controls] consisted of 20 volunteers who were not complaining of any allergic manifestations. The study showed that there was a positive correlation between total half life of plasma clearance of 99mTc-sulphur colloid and Forced expiratory volume in one second [FEVl] among intrinsic asthmatic patients but there was no significant difference between intrinsic asthmatic patients and control group as regard total half life of plasma clearance of 99mTc-sulphur colloid denoting that hepatic macrophages Kupffer cells are functionally active in the intrinsic asthmatic patients