Hepatic encephalopathy an approach using brainmapping and the quantitative pharmaco-EEG methology
Ain-Shams Medical Journal. 1995; 46 (1-2-3): 137-147
in English
| IMEMR
| ID: emr-36054
ABSTRACT
In the present study 20 patients with stage II or stage III hepatic encephalopathy were examined by brainmapping and the quantitative pharmaco-EEG methodology. The spectral profile demonstrated in all patients was identical to the pharmaco-EEG profile of the Benzodiazepine [BNZ] receptor agonists [diazepam for example]. This spectral profile was instantanously normalised by injection of flumazenil [Anexate], which is a specific BNZ receptor antagonist. These findings indicate that functional increase in the GABA-ergic tone is the aetiopathogenic factor responsible for the clinical and etectrophysiological changes observed in hepatic enphalopthy and they also indicate that these functional increases in the GABA-ergic tone is mediated allosterically through pathological activation of the brain BNZ receptors probably by endogenous substances with diazepam-Like properties. The implication of these results on the management of hepatic encephalopathy will be discussed
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Signs and Symptoms
/
Brain Mapping
/
Flumazenil
/
Treatment Outcome
/
Diazepam
/
Electrocardiography
/
Abdomen
/
Kidney Function Tests
/
Liver Function Tests
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Ain-Shams Med. J.
Year:
1995
Similar
MEDLINE
...
LILACS
LIS