Novel pyidopyrimidinedione analogs as possible anticonvulsants

ABSTRACT

Novel pyrido [2,3-d] pyrimidine-2,4-dione derivatives were synthesized as anticonvulsant agents. The proposed compounds possess bio- isosteric relationships to quinazolinone analogs and to ethosuximide agent. Anti-MMS assays were conducted for six of the newly synthesized compounds [VIIIa, IX, XII, XV, XVII, XX] in relevance to ethosuximide as reference st and ard. The results revealed that compound VIIIa was the most effective and displayed 60% protection