Comparative clinical trial of sodium valproate and carbamazepine in Egyptian patients with epilepsy
Benha Medical Journal. 1995; 12 (2): 203-210
in English
| IMEMR
| ID: emr-36558
ABSTRACT
This study was carried out on 40 Egyptian epileptic patients, 20 on valproate [30 - 50 mg/kg oral/day] and 20 patients were on carbamazepine [20 - 40 mg/kg/oral/day]. Results of the present work demonstrated that some adverse effects higher in valproate monotherapy than carbamazepine monotherapy as tremors [10%], weight gain [20%] and appetite gain [10%], but others were higher in carbamazepine monotherapy than valproate monotherapy like headache [10%], rash [10%] and gastrointestinal troubles [15%]. Moreover some side effects occurred with carbamazepine monotherapy like decreased lipido [5%] but not with valproate. Also, there were no significant hematological changes either with valproate or carbamazepine, Moreover, SGOT, SGPT and total bilirubin were significantly elevated [p = 0.05] in valproate not with carbamazepine monotherapy. Finally, this Study sufficiently provide useful informations of adverse events when treating adult patients with monotherapy with valproate or carbamazepine in a neurological out patient clinic in Benha University Hospital
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Comparative Study
/
Valproic Acid
/
Hematologic Tests
/
Liver Function Tests
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Benha Med. J.
Year:
1995
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