Serum type IV collagen concentrations in patients with longstanding essential hypertension

ABSTRACT

Relation between LS EHT and type IV serum collagen concentration was estimated by RIA. The ACV was estimated from CXR, PA view and it lateral view with barium and RCV was deduced. Twenty-two patients with LS EHT were chosen. Ten normal persons were taken as a control group. Serum collagen concentration and RCV were found to be significantly high in the patients group [P <0.01 and P <0.05, respectively]. A positive correlation was found between serum collagen concentration and RCV [r = 0.97] and another positive correlation was also found between DBP and serum collagen concentration [r = 0.74]. It was concluded that LS EHT has an effect on the capillary basement membrane. It may increase the synthesis, the deposition and the turn over the type IV serum collagen. Serum type IV collagen concentration is a useful noninvasive marker for the activity and progression of hypertension